Select Cannabis Regulatory Science Publications
Zamarripa, C. A., Tilton, H. E., Lin, S., Cone, E. J., Winecker, R. E., Flegel, R. R., Kuntz, D., Beals, M., Jaques, M., Clark, M., Welsh, E. R., Wagner, L., Bonn-Miller, M. O., Vandrey, R., & Spindle, T. R. (2024). Pharmacokinetics and pharmacodynamics of five distinct commercially available hemp-derived topical cannabidiol (CBD) products. Journal of Analytical Toxicology, https://doi.org/10.1093/jat/bkae001
Jenkins BJ, Moore CF, Covey D, McDonald J, Lefever TW, Bonn-Miller MO, Weerts, E.M. Evaluating potential anxiolytic effects of minor cannabinoids and terpenes after acute and chronic oral administration in rats. Cannabis and Cannabinoid Research, 2023, Volume 8, Supplement 1, DOI: 10.1089/can.2023.0083Moore CF, Weerts E.M., KulpaJ, Schwotzer D, DyeW, JantziJ, McDonald JD, LefeverTW, Bonn-MillerMO. Pharmacokinetics of oral minor cannabinoids in blood and brain. Cannabis and Cannabinoid Research, 2023 Volume 8, Supplement 1, S51-S61 doi.org/10.1089/can.2023.0066
Moore CF, Marusich J, Haghdoost M, LefeverT, Bonn-MillerM, Weerts, E.M. Evaluation of modulatory effects of minor cannabinoids and terpenes on THC discrimination in rats. Cannabis and Cannabinoid Research, 2023 Volume 8, Supplement 1, S42–S50, DOI: 10.1089/can.2023.0062
Sumit Bansal, C. Austin Zamarripa, Tory R. Spindle, Elise M. Weerts, Kenneth E. Thummel, Ryan Vandrey, Mary F. Paine, Jashvant D. Unadkat. Evaluation of Cytochrome P450-Mediated Cannabinoid-Drug Interactions in Healthy Adult Participants. ASCPT. 2023.
Dowd, A.N., Zamarripa, C.A., Sholler, D.J., Strickland, J.C., Goffi, E., Borodovsky, J.T., Weerts, E.M., Vandrey, R., Spindle, T.R. A Cross-Sectional Survey on Cannabis: Characterizing Motives, Opinions, and Subjective Experiences Associated with the use of Various Oral Cannabis Products. Drug and Alcohol Dependence (April 2023).
Moore, C. F., Davis, C. M., Sempio, C., Klawitter, J., Christians, U., & Weerts, E. M. Effects of oral Δ9-tetrahydrocannabinol and cannabidiol combinations on a sustained attention task in rats. Experimental and Clinical Psychopharmacology. Experimental and Clinical Psychopharmacology, 31(5), 881–887. https://doi.org/10.1037/pha0000635
Spindle T, Sholler D, Cone E, Murphy T, ElSohly M, Winecker R, Flegel R, Bonn-Miller M, Vandrey, R. Cannabinoid Content and Label Accuracy of Hemp-Derived Topical Products Available Online and at National Retail Stores. J Am Med Assoc. 2022; 5(7):e2223019
Moore, C. F., Weerts, E. M. Cannabinoid tetrad effects of oral Δ9‑tetrahydrocannabinol (THC) and cannabidiol (CBD) in male and female rats: sex, dose‑effects and time course evaluations. Psychopharmacology volume 239, pages 1397–1408 (2022)
Moore, C. F., Davis, C. M., Sempio, C., Klawitter, J., Christians, U., & Weerts, E. M. Δ9-Tetrahydrocannabinol Vapor Exposure Produces Conditioned Place Preference in Male and Female Rats. Cannabis and Cannabinoid Research. Ahead of Print Published Online: 30 Sep 2022.
Spindle TR, Bonn-Miller MO, Vandrey R. Changing Landscape of Cannabis: Novel Products, Formulations, and Methods of Administration. Curr Opin Psychol. 2019; 30; 98-102.
Sholler DJ, Spindle TR, Cone EJ, Goffi E, Kuntz D, Mitchell JM, Winecker RE, Bigelow GE, Flegel R, Vandrey R. Urinary Pharmacokinetic Profile of Cannabidiol (CBD), Δ9-Tetrahydrocannabinol (THC), and their Metabolites Following Oral and Vaporized CBD and Vaporized CBD-Dominant Cannabis Administration. J Anal Tox. In press.
Spindle TR, Martin E, Grabenauer M, Woodward T, Milburn MA, Vandrey R. Assessment of Cognitive and Psychomotor Impairment, Subjective Effects, and Blood THC Concentrations Following Acute Administration of Oral and Vaporized Cannabis. J Psychopharmacol. 2021; 35(7):786-803.
Sholler DJ, Moran MB, Dolan SB, Borodovsky JT, Alonso F, Vandrey R, Spindle TR. Use Patterns, Beliefs, Experiences, and Behavioral Economic Demand of Indica and Sativa Cannabis: A Cross-Sectional Survey of Cannabis Users. Exp Clin Psychopharm. ePub April 15, 2021.
Arkell T, Spindle T, Kevin R, Vandrey R, McGregor I. The failings of per se limits to detect cannabis-induced driving impairment: results from a simulated driving study. Traffic Injury Prevention. 2021; 22; 102-107.
Sholler DJ, Strickland JC, Spindle TR, Weerts EM, Vandrey R. Sex differences in the acute effects of oral and vaporized cannabis among healthy adults. Addict Biol ePub Sept 28, 2020.
Spindle TR, Cone EJ, Herrmann ES, Mitchell JM, Flegel R, LoDico C, Bigelow GE, Vandrey R. Pharmacokinetics of Cannabis Brownies: A Controlled Examination of Δ9-Tetrahydrocannabinol and Metabolites in Blood and Oral Fluid of Healthy Adult Males and Females. J Anal Toxicol. 2020; 44; 661–671.
Schlienz NJ, Spindle TR, Cone EJ, Herrmann ES, Bigelow GE, Mitchell JM, Flegel R, LoDico C, Vandrey R. Pharmacodynamic dose effects of oral cannabis ingestion in healthy adults who infrequently use cannabis. Drug Alc Depend. ePub March 21, 2020.
Spindle TR, Cone EJ, Goffi E, Weerts EM, Mitchell JM, Winecker RE, Bigelow GE, Flegel R, Vandrey R. Pharmacodynamic effects of vaporized and oral cannabidiol (CBD) and vaporized CBD-dominant cannabis in infrequent cannabis users. Drug Alc Depend. 2020; 211; 107937.
Spindle TR, Cone EJ, Kuntz D, Mitchell JM, Bigelow GE, Flegel R, Vandrey R. Urinary pharmacokinetic profile of cannabinoids following administration of vaporized and oral cannabidiol (CBD) and vaporized CBD-dominant cannabis. J Anal Tox. 2020; 44; 109-125.
Arkell TR, Lintzeris N, Ramaekers JG, Vandrey R, Irwin C, Haber PS, Kevin R, McGregor IS. Cannabidiol (CBD) content in vaporized cannabis does not prevent tetrahydrocannabinol (THC)-induced impairment of driving and cognition. Psychopharmacology. 2019; 236; 2713-2724.
Spindle TR, Cone EJ, Schlienz NJ, Mitchell JM, Bigelow GE, Flegal R, Hayes E, Vandrey R. Acute Effects of Smoked and Vaporized Cannabis in Healthy Adults Who Infrequently Use Cannabis: A Cross-Over Trial. JAMA Netw Open. 2018; 1; e184841, 1-14.
Bonn-Miller MO, Loflin MJE, Thomas BF, Marcu JP, Hyke T, Vandrey R. Label accuracy of cannabidiol extracts sold online. J Am Med Assoc. 2017; 318; 1708-1709.
Vandrey R, Raber JC, Raber ME, Douglass B, Miller C, Bonn-Miller MO. Cannabinoid Dose and Label Accuracy In “Edible” Medical Cannabis Products. J Am Med Assoc. 2015; 313; 2491-2493