Controlled clinical trials on the therapeutic efficacy and potential adverse effects of medicinal cannabis/cannabinoid use for individuals with a variety of health conditions (e.g. pain, anxiety, depression, epilepsy, autism, multiple sclerosis, dementia).

Preclinical studies on the effects of cannabis/cannabinoids on mood, pain, stress/anxiety-related disorders and mitigation of opioid withdrawal.

Longitudinal observational “real-world” studies of individuals using cannabis for therapeutic purposes.

Evaluation of drug-drug interactions between cannabis/cannabinoids and other drugs (e.g., alcohol, nicotine, and prescription or OTC medications).

Understanding neurobiological mechanisms of cannabis effects via advanced brain imaging and preclinical studies of endocannabinoid system modulation in models of psychiatric illness (e.g. addiction, stress-related disorders).

Evaluation of how individual differences (e.g. sex, age, tolerance) impact the risks and benefits of cannabis use.