Nicotine/Tobacco Research @ CSL

Brain imaging of nicotinic acetylcholine receptors in tobacco users and nonusers

This research is being done to learn more about neurological differences in the brains of people who smoke cigarettes and includes an 8-day practice quit attempt. These results will help us understand how the brain can change as a result of smoking cigarettes.

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This is an outpatient study and does not require any overnight stays. If you are eligible and wish to participate in the study, you will make a practice quit attempt where you will be asked to not smoke or use any nicotine products for at least 1 day and have the option to try to not smoke for up to 8 days. 

Urine and breath samples will be collected each visit and you will receive additional payment(s) if your test results show you did not smoke during your attempt. This payment for successfully not smoking is an incentive to help you remain abstinent.

Total compensation for this research study is up to $645.

If eligible, we will invite you to complete the following procedures:

  • 3 study visits on weekdays.
    • Visit 1 –where you smoke cigarettes as usual and have 1 MRI Scan
    • Visit 2 –1 PET Scan. You must be able to not smoke for at least 1 day in order to complete the PET scan
    • Visit 3 –one week after the PET scan to see if you were able to remain abstinent

If you are interested in this study, please click this link to see if you are eligible.

Behavioral Pharmacology of Cannabis and Nicotine

This study evaluates the individual and interactive pharmacokinetic and pharmacodynamic effects of smoked cannabis and nicotine.

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Healthy volunteers age 18-55 are needed to take part in a research study at Johns Hopkins. We are seeking people who currently smoke cigarettes or vape nicotine at least daily and have used cannabis at least once in the past month. Participants will be paid up to $1730 for study completion. Study involves smoking cannabis and also smoking a tobacco cigarette or vaping with an e-cigarette over 7 experimental sessions.

If you are interested in this study, please refer to this page.

Acute Pharmacokinetic and Pharmacodynamic Effects of “Tobacco-Free” Oral Nicotine Pouches in Smokers

This research is being done to learn more about the short-term effects of oral nicotine pouches, including subjective and cardiovascular effects and also to understand nicotine pharmacokinetics (or how the drug moves through your body) from nicotine pouches in comparison to tobacco cigarettes. Nicotine pouches are becoming more popular and are widely available in retail stores such as tobacco shops and gas stations. However, to date, there has not been much research done to understand the effects of these pouches in tobacco cigarette smokers.

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The purpose of this study is to learn more about the effects of using oral nicotine pouches of different flavors and nicotine strengths in comparison to regular cigarettes. If you are eligible and join this study, you will complete 1 screening visit that lasts about 2 hours and 7 drug administration sessions that each last about 5 hours.

Healthy adults over the age of 21 may join the study. Total possible earnings will be $1030.

If you are interested in this study, please refer to this page.